3D free-breathing cardiac magnetic resonance fingerprinting
3D free-breathing cardiac magnetic resonance fingerprinting
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DOI：
10.1002/nbm.4370
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发表时间：
2020-07-21
影响因子：
2.9
通讯作者：
Prieto, Claudia
中科院分区：
文献类型：
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作者：
Cruz, Gastao;Jaubert, Olivier;Prieto, Claudia
目的开发一种新的呼吸运动补偿三维（3D）心脏磁共振指纹（cMRF）方法，用于全心脏心肌alt(1)和t(2)的自由呼吸扫描。最近，二维（2D） cMRF被提出用于同时，共同注册t(1)和t(2)映射从屏息扫描；然而，覆盖面是有限的。在这里，我们提出了一种新的呼吸运动补偿3D cMRF方法，用于全心脏心肌alt(1)和t(2)组织特征的自由呼吸扫描。采用变量反演恢复和t(2)准备模块进行参数编码，采用呼吸风箱驱动的局部自动聚焦进行拍间平移运动校正，采用子空间正则化重构加速扫描。在标准T(1)/T(2)模型中与参考自旋回波值进行了比较，并在10名健康受试者中与标准2D MOLLI、SASHA和T(2)-GraSE作图技术在1.5 T时进行了比较。结果3D cMRFT(1)和T(2)测量值与参考自旋回波值基本吻合，相对误差分别为2.9%和3.8% forT(1)和T(2)（T-2< 100 ms）。体内左心室（LV）心肌alt(1)值MOLLI为1054 +/- 19 ms， SASHA为1146 +/- 20 ms， 3D cMRF为1093 +/- 24 ms；T2-GraSE的t(2)值为51.8 +/- 1.6 ms， 3D cMRF的t(2)值为44.6 +/- 2.0 ms。MOLLI的LV变异系数为7.6 +/- 1.6%，SASHA为12.1 +/- 2.7%，3D cMRFT为5.8 +/- 0.8% (1)，T2-GraSE为10.5 +/- 1.4%，3D cMRFT为11.7 +/- 1.6%(2)。结论所提出的三维cMRF可以在单次约7 min的自由呼吸扫描中提供全心，同时和共同注册的t(1)和t(2)图，其准确度和精度可与临床标准相媲美。
Purpose To develop a novel respiratory motion compensated three-dimensional (3D) cardiac magnetic resonance fingerprinting (cMRF) approach for whole-heart myocardialT(1)andT(2)mapping from a free-breathing scan. Methods Two-dimensional (2D) cMRF has been recently proposed for simultaneous, co-registeredT(1)andT(2)mapping from a breath-hold scan; however, coverage is limited. Here we propose a novel respiratory motion compensated 3D cMRF approach for whole-heart myocardialT(1)andT(2)tissue characterization from a free-breathing scan. Variable inversion recovery andT(2)preparation modules are used for parametric encoding, respiratory bellows driven localized autofocus is proposed for beat-to-beat translation motion correction and a subspace regularized reconstruction is employed to accelerate the scan. The proposed 3D cMRF approach was evaluated in a standardizedT(1)/T(2)phantom in comparison with reference spin echo values and in 10 healthy subjects in comparison with standard 2D MOLLI, SASHA andT(2)-GraSE mapping techniques at 1.5 T. Results 3D cMRFT(1)andT(2)measurements were generally in good agreement with reference spin echo values in the phantom experiments, with relative errors of 2.9% and 3.8% forT(1)andT(2)(T-2< 100 ms), respectively. in vivo left ventricle (LV) myocardialT(1)values were 1054 +/- 19 ms for MOLLI, 1146 +/- 20 ms for SASHA and 1093 +/- 24 ms for the proposed 3D cMRF; correspondingT(2)values were 51.8 +/- 1.6 ms for T2-GraSE and 44.6 +/- 2.0 ms for 3D cMRF. LV coefficients of variation were 7.6 +/- 1.6% for MOLLI, 12.1 +/- 2.7% for SASHA and 5.8 +/- 0.8% for 3D cMRFT(1), and 10.5 +/- 1.4% for T2-GraSE and 11.7 +/- 1.6% for 3D cMRFT(2). Conclusion The proposed 3D cMRF can provide whole-heart, simultaneous and co-registeredT(1)andT(2)maps with accuracy and precision comparable to those of clinical standards in a single free-breathing scan of about 7 min.