Endplate Deflection Is a Defining Feature of Vertebral Fracture and Is Associated With Properties of the Underlying Trabecular Bone
Endplate Deflection Is a Defining Feature of Vertebral Fracture and Is Associated With Properties of the Underlying Trabecular Bone
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DOI：
10.1002/jor.22620
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发表时间：
2014-07-01
影响因子：
2.8
通讯作者：
Morgan, Elise F.
中科院分区：
文献类型：
--
作者：
Jackman, Timothy M.;Hussein, Amira I.;Morgan, Elise F.
终板偏转经常发生在椎体失效时，但两者之间的关系仍不明确。本研究探讨了终板在压缩载荷下的变形与邻近的软骨下骨和椎间盘（IVD）特征之间的关系。在每个加载步骤之前，解剖10个具有相邻IVD的L1椎骨，以逐步的方式轴向压缩至失效，并进行显微计算机断层扫描成像。根据图像，在每个步骤测量每个终板表面的偏转。在上级终板下方5 mm区域评价骨小梁显微结构和终板体积分数。使用计算机断层扫描和组织学评估IVD。上级终板挠度的显著增加与载荷-位移曲线的下降相一致。在骨微结构不太坚固的区域，终板偏转更高（p
Endplate deflection frequently occurs with vertebral failure, but the relationship between the two remains poorly defined. This study examined associations between endplate deflection under compressive loading and characteristics of the neighboring subchondral bone and intervertebral disc (IVD). Ten L1 vertebrae with adjacent IVDs were dissected, compressed axially in a stepwise manner to failure, and imaged with micro-computed tomography before each loading step. From the images, deflection was measured across the surface of each endplate at each step. Trabecular microstructure and endplate volume fraction were evaluated in 5mm regions just under the superior endplate. IVDs were assessed using computed tomography and histology. A marked increase in superior endplate deflection coincided with a drop in the load-displacement curve. Endplate deflection was higher in regions with less robust bone microstructure (p