Four New Macrocyclic Trichothecenes from Two Strains of Marine-derived Fungi of the Genus Myrothecium
Four New Macrocyclic Trichothecenes from Two Strains of Marine-derived Fungi of the Genus Myrothecium
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DOI：
10.1038/ja.2006.63
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发表时间：
2006-08
期刊：
影响因子：
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通讯作者：
Jinzhong Xu;A. Takasaki;Hisayoshi Kobayashi;T. Oda;J. Yamada;R. E. Mangindaan;K. Ukai;H. Nagai
中科院分区：
文献类型：
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作者：
Jinzhong Xu;A. Takasaki;Hisayoshi Kobayashi;T. Oda;J. Yamada;R. E. Mangindaan;K. Ukai;H. Nagai
从海源真菌Myrothecium roridum TUF 98F42中分离到3个新的大环霉霉烯，分别命名为12′-羟基霉霉素E(1)、霉霉素Q(2)和2′，3′-脱氧霉毒素D(3)；从Myrothecium sp. TUF 02F6中分离到1个新的大环霉霉烯，命名为霉霉素R(4)，并与霉霉素a、H和异霉霉素E一起进行了结构分析。化合物2在1的13′位置上有一个独特的醚段。化合物1、2和4对小鼠白血病细胞株L1210的ic50值分别为0.19、31.2和0.45 μM。化合物3对酿酒酵母菌的抑菌活性为1 μg/碟（抑制区：12.2 mm），是酵母毒素D（抑制区：10.2 mm， 10 μg/碟）的10倍左右。
Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′, 3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′, 3′-dihydro-2′-hydroxy derivative of roridin H. The IC 50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2 mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).