The effects of morphine on responding under variable-interval schedules: rate-related effects, behavioral mechanisms and Herrnstein's hyperbola.
The effects of morphine on responding under variable-interval schedules: rate-related effects, behavioral mechanisms and Herrnstein's hyperbola.
复制标题
吗啡对可变间隔计划下反应的影响：速率相关效应、行为机制和赫恩斯坦双曲线。
DOI：
10.1097/00008877-199907000-00001
复制
发表时间：
1999
影响因子：
1.6
通讯作者：
Dallery,J
中科院分区：
文献类型：
--
作者：
Lancaster,JS;Dallery,J
本研究旨在整合速率相关原理和Herrnstein的双曲匹配方程（1970），因为它们适用于药物效应。它也被设计用来评估解释用于解释药物作用的行为机制的Herrnstein方程的有效性。八只大鼠进行训练，按下一系列的可变间隔（VI）的强化计划，使用蔗糖溶液（0.1 M）作为一种替代品的杠杆。在90个基线期后，测试了硫酸吗啡3、6、12和17 mg/kg对反应的影响。吗啡给药后，反应率以剂量依赖性方式受到抑制。Herrnstein的方程指出，反应是相对强化率的函数，在大多数情况下，反应和强化之间的关系提供了一个很好的描述。因此，将用于预测频率依赖性函数中药物效应的传统变量基线缓解率与新变量基线相对强化率进行比较。相对强化率和反应率在预测药物作用方面表现良好。为了测试Herrnstein双曲线是否可以识别吗啡作用的行为机制，增加蔗糖溶液的浓度（0.32M）。Herrnstein方程的y-渐近线k随蔗糖浓度的增加而增加。这就对Herrnstein方程的一种常见解释提出了质疑，该方程用于确定药物作用的行为机制。
: The study was designed to integrate rate-related principles and Herrnstein's hyperbolic matching equation (1970) as they apply to drug effects. It was also designed to assess the validity of an interpretation of Herrnstein's equation used to account for the behavioral mechanisms of drug action. Eight rats were trained to press a lever under a range of variable-interval (VI) schedules of reinforcement using sucrose solution (0.1 M) as a reinforcer. After 90 baseline sessions the effect of morphine sulfate, 3, 6, 12 and 17 mg/kg, on responding was tested. Response rates were suppressed in a dose-dependent manner after morphine administration. Herrnstein's equation, which states that responding is a function of relative reinforcement rate, provided a good description of the relationship between responding and reinforcement under most conditions. Therefore, the traditional variable used to predict the drug effect in rate-dependency functions, baseline response rate, was compared to a new variable, baseline relative reinforcement rate. Relative reinforcement rate performed as well as response rate in predicting the drug effect. In order to test if Herrnstein's hyperbola can identify the behavioral mechanisms of the action of morphine, the concentration of the sucrose solution was increased (0.32 M). The y-asymptote of Herrnstein's equation, k, increased as sucrose concentration increased. This calls into question one common interpretation of Herrnstein's equation used to identify the behavioral mechanisms of drug action.