Some viral microRNAs were up‐regulated in megakaryocytes incubated with immune thrombocytopenia plasma
Some viral microRNAs were up‐regulated in megakaryocytes incubated with immune thrombocytopenia plasma
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DOI：
10.1111/ejh.12063
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发表时间：
2013-03
影响因子：
3.1
通讯作者：
Ya Wang;R. Huang;Chao-Yang Song;Haiyan Hu;Meixia Zhang
中科院分区：
文献类型：
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作者：
Ya Wang;R. Huang;Chao-Yang Song;Haiyan Hu;Meixia Zhang
MicroRNA (miRNA) 已被证明在造血过程中发挥重要作用，例如巨核细胞生成。虽然骨髓中巨核细胞不成熟是免疫性血小板减少症（ITP）最典型的特征之一，而ITP往往先于病毒感染发生，但迄今为止尚无病毒miRNA、巨核细胞成熟度与ITP之间关系的报道。本研究旨在调查病毒 miRNA 是否通过调节巨核细胞的产生等方式参与 ITP 的发病机制。
MicroRNAs (miRNAs) have been shown to play important roles in hematopoiesis, such as megakaryocytopoiesis. Although immature megakaryocytes in bone marrow are one of the most typical characteristics of immune thrombocytopenia (ITP) which is often preceded by viral infection, there has been so far no report on the relationship between viral miRNAs, maturity of megakaryocytes, and ITP. This study aims to investigate whether viral miRNAs are involved in the pathogenesis of ITP, for example, by modulating the production of megakaryocytes.