Expedient synthesis and design strategies for new peptoid construction
Expedient synthesis and design strategies for new peptoid construction
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DOI：
10.1021/ol0502984
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发表时间：
2005-04-14
期刊：
影响因子：
5.2
通讯作者：
Blackwell, HE
中科院分区：
文献类型：
--
作者：
Gorske, BC;Jewell, SA;Blackwell, HE
[图表]在商业反应器中使用微波辅助固相化学可以有效制备一系列类肽。该方法对于安装电子失活的苄胺是最有效的。将这些胺系统地掺入类肽中可以产生能够显示独特且稳定的结构基序的寡聚物——微波辅助固相合成将使它们未来的研究和应用成为可能。
[GRAPHICS]A range of peptoids can be prepared efficiently using microwave-assisted solid-phase chemistry in a commercial reactor. This method is most effective for the installation of electronically deactivated benzylic amines. The systematic incorporation of these amines into peptoids can deliver oligomers capable of displaying unique and stable structural motifs-microwave-assisted solid-phase synthesis will enable their future study and application.