Trait anxiety mediates the link between inferior frontal cortex volume and negative affective bias in healthy adults
Trait anxiety mediates the link between inferior frontal cortex volume and negative affective bias in healthy adults
复制标题
DOI：
10.1093/scan/nsx008
复制
发表时间：
2017-05-01
影响因子：
4.2
通讯作者：
Dolcos, Sanda
中科院分区：
文献类型：
--
作者：
Hu, Yifan;Dolcos, Sanda
焦虑的人往往会在注意力方面表现出消极的情感偏差，这可能反映了执行控制的减少，执行控制是一种与下额皮质（IFC）相关的认知功能，特别是其后段，盖部。在这里，我们研究了健康参与者的 IFC 岛盖部灰质体积、特质焦虑和注意力负面偏差之间的关系。 62 名成年人接受了结构磁共振成像扫描，完成了特质焦虑测量，并执行了情感进行/不进行（AGN）任务。使用 Freesurfer 提取 IFC 体积，并根据 AGN 性能计算负偏差分数。特质焦虑与左IFC体积呈负相关，与反应时间的负偏差呈正相关。此外，特质焦虑介导了 IFC 数量和负偏差测量之间的负相关关系。总体而言，目前的研究结果扩展了之前对国际金融公司在结构层面参与焦虑的理解，并可能为针对焦虑的干预计划的制定提供信息。
Anxious individuals tend to show a negative affective bias in attention that likely reflects reduced executive control, a cognitive function associated with the inferior frontal cortex (IFC), particularly its posterior segment, pars opercularis. Here, we investigated the relations among gray matter volume in the pars opercularis of IFC, trait anxiety, and negative biases in attention, in healthy participants. Sixty-two adults underwent structural magnetic resonance imaging scanning, completed a trait anxiety measure, and performed an Affective Go/No-Go (AGN) task. IFC volumes were extracted using Freesurfer, and negative bias scores were calculated from AGN performance. Trait anxiety correlated negatively with left IFC volume, and positively with the negative bias in reaction time. Furthermore, trait anxiety mediated the negative relation between the IFC volume and the negative bias measure. Overall, the present findings extend previous understanding of the IFC involvement in anxiety at the structural level, and may inform the development of intervention programs targeting anxiety.