Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism.
Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism.
复制标题
脑室内神经肽 Y 通过迷走神经机制刺激胆汁分泌。
作者：
Farouk,M;Geoghegan,JG;Pruthi,RS;Thomson,HJ;Pappas,TN;Meyers,WC
在已准备好胃和十二指肠瘘以及脑室导管的清醒狗中，研究了脑室内注射神经肽Y对胆汁分泌的影响。脑室内神经肽 Y 以剂量依赖性方式增加胆汁分泌。在 500 pM/kg 神经肽 Y 后出现峰值增加，导致注射后 30-150 分钟内胆汁流量增加 30 x 2%。 （对照：23 x 2 (1 x 2) ml/2 小时；神经肽 Y 500 pM/kg：30 x 5 (1 x 1) ml/2 小时）。在所有测试剂量下，胆汁脂质成分没有显着改变，但碳酸氢盐输出增加。静脉输注神经肽Y（1000 pM）1小时无明显效果。脑室内神经肽 Y（1000 pM/250-300 mg 体重）也增加了乌拉坦麻醉大鼠的胆汁流量。这种效应被宫颈迷走神经切断术消除了。碱性胆汁流的中枢刺激表明胆汁分泌可能受到中枢调节。
The effect of intracerebroventricular injection of neuropeptide Y on biliary secretion was studied in conscious dogs, prepared with gastric and duodenal fistulas and cerebroventricular guides. Bile secretion was increased in a dose-dependent fashion by intracerebroventricular neuropeptide Y. The peak increase was seen after 500 pM/kg of neuropeptide Y which resulted in a 30 x 2% increase in bile flow over the period 30-150 minutes after injection. (Control: 23 x 2 (1 x 2) ml/2 hours; neuropeptide Y 500 pM/kg: 30 x 5 (1 x 1) ml/2 hours). Biliary lipid composition was not altered significantly but bicarbonate output was increased at all doses tested. Intravenous infusion of neuropeptide Y (1000 pM) for 1 hour had no significant effect. Intracerebroventricular neuropeptide Y (1000 pM/250-300 mg body weight) also increased bile flow in urethane-anaesthetised rats. This effect was abolished by cervical vagotomy. The demonstration of a central stimulation of alkaline bile flow suggests that bile secretion may be subject to central modulation.