Paraoxonase-1 reduces monocyte chemotaxis and adhesion to endothelial cells due to oxidation of palmitoyl, linoleoyl glycerophosphorylcholine
Paraoxonase-1 reduces monocyte chemotaxis and adhesion to endothelial cells due to oxidation of palmitoyl, linoleoyl glycerophosphorylcholine
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DOI：
10.1016/s0008-6363(02)00659-4
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发表时间：
2003-01-01
影响因子：
10.8
通讯作者：
Connelly, PW
中科院分区：
文献类型：
--
作者：
Ahmed, Z;Babaei, S;Connelly, PW
目的：高密度脂蛋白（HDL）被认为部分地通过抑制内皮下空间中低密度脂蛋白（LDL）的氧化从而抑制内皮的活化来防止动脉粥样硬化的发展。HDL相关酶，对氧磷酶-1，被认为是一个主要的保护因素。然而，当暴露于过氧亚硝酸盐时，HDL也易于氧化，因此一旦氧化，可能具有与氧化的LDL相似的性质。方法与结果：我们将人HDL暴露于过氧亚硝酸盐供体3-morpholinosydnonimine，并将氧化的HDL与人脐静脉内皮细胞（HUVECs）孵育。氧化HDL增加单核细胞结合（P
Objective: High-density lipoprotein (HDL) is postulated to protect against the development of atherosclerosis, in part, by inhibiting the oxidation of low density lipoprotein (LDL) in the sub-endothelial space and thus inhibiting activation of the endothelium. The HDL-associated enzyme, paraoxonase-1, is proposed to be a major protective factor. However, HDL is also prone to oxidation when exposed to peroxynitrite and may therefore, once oxidized, have properties similar to oxidized LDL. Methods and results: We exposed human HDL to the peroxynitrite donor 3-morpholinosydnonimine and incubated oxidized HDL with human umbilical vein endothelial cells (HUVECs). Oxidized HDL increased monocyte binding (P