eagle is required for the specification of serotonin neurons and other neuroblast 7-3 progeny in the Drosophila CNS.
eagle is required for the specification of serotonin neurons and other neuroblast 7-3 progeny in the Drosophila CNS.
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发表时间：
1998-02
期刊：
影响因子：
4.6
通讯作者：
Martha J. Lundell;Jay Hirsh
中科院分区：
文献类型：
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作者：
Martha J. Lundell;Jay Hirsh
在果蝇神经索的发育过程中，成神经细胞7-3在每个半节中产生一对有丝分裂的姐妹5-羟色胺神经元。在这里，我们表明，锌指基因鹰，这是在成神经细胞7-3，是必不可少的指定的命运的5-羟色胺神经元。我们发现，功能丧失的鹰突变产生一个不寻常的差异表型相对于姐妹血清素细胞和鹰是必要的，在5-羟色胺神经元中的表达的维持和zfh-2。我们提出了一个模型，唯一地确定所有后代神经元的神经母细胞7-3谱系的基础上表达的特定分子标记物，在神经索内的位置和鹰功能丧失突变的影响。虽然5-羟色胺是一种重要的神经递质保守的整个动物王国，我们表明，亚纯等位基因的鹰可以产生可行的成年人，有显着减少的神经元的数量。
During development of the Drosophila nerve cord, neuroblast 7-3 gives rise to a pair of mitotic sister serotonin neurons in each hemisegment. Here we show that the zinc finger gene eagle, which is expressed in neuroblast 7-3, is essential for specifying the fate of serotonin neurons. We find that loss-of-function eagle mutations produce an unusual differential phenotype with respect to the sister serotonin cells and that eagle is necessary for the maintenance of engrailed and zfh-2 expression in the serotonin neurons. We present a model that uniquely identifies all progeny neurons in the neuroblast 7-3 lineage based on the expression of specific molecular markers, position within the nerve cord and the effect of eagle loss-of-function mutations. Although serotonin is an important neurotransmitter conserved throughout the animal kingdom, we show that hypomorphic alleles of eagle can produce viable adults that have a dramatic reduction in the number of serotonin-producing neurons.