Using stable isotopes to assess mineral absorption and utilization by children.
Using stable isotopes to assess mineral absorption and utilization by children.
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DOI：
10.1093/ajcn/70.6.955
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发表时间：
1999-12
期刊：
影响因子：
--
通讯作者：
S. Abrams
中科院分区：
文献类型：
--
作者：
S. Abrams
充足的矿物质摄入量是儿童健康饮食的重要组成部分，它支持适当的生长和发育，保护儿童免受贫血等儿童疾病的影响，并有助于预防未来的成人疾病，如骨质疏松症。在婴儿和儿童中进行和解释研究方面的挑战阻碍了对其矿物利用的准确评估。成人使用的许多最强大的技术，如放射性同位素测试，不适合儿童使用。近年来，先进的矿物稳定同位素技术已经被开发出来，以填补这一空白。儿科应用包括青春期钙吸收和动力学的研究，以及婴儿和幼儿钙-铁相互作用的评估。遗传学在决定钙吸收和骨转换中的作用可能成为一个重要的研究领域。本报告探讨了正在进行的婴幼儿矿物质稳定同位素研究的目标和方法。在过去，获得同位素的成本和困难限制了这类研究。这种情况已有相当大的改善，尽管准备进行样本分析的营养研究实验室相对较少。
Adequate mineral intake is a crucial part of a healthy diet for children-it supports appropriate growth and development and provides protection against childhood conditions like anemia and helps to prevent future adult diseases such as osteoporosis. Challenges in performing and interpreting studies in infants and children have hampered the accurate assessment of their mineral utilization. Many of the most powerful techniques used in adults, such as radioisotope testing, are not appropriate for use in children. In recent years, advanced mineral stable-isotope techniques have been developed to fill this gap. Pediatric applications include studies of calcium absorption and kinetics during puberty and evaluation of the calcium-iron interaction in infants and toddlers. The effects of genetics in determining calcium absorption and bone turnover may become an important research area. The goals and methods of ongoing mineral stable-isotope research in infants and children are examined in this report. In the past, the cost and difficulties in obtaining isotopes have limited such research. This situation has improved considerably, although relatively few nutrition research laboratories are prepared to perform sample analyses.