DISTRIBUTION OF INTRA-RENAL BLOOD-FLOW DURING BACTERIAL SEPSIS
DISTRIBUTION OF INTRA-RENAL BLOOD-FLOW DURING BACTERIAL SEPSIS
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DOI：
10.1016/0022-4804(78)90165-8
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发表时间：
1978-01-01
影响因子：
2.2
通讯作者：
LINDENAUER, SM
中科院分区：
文献类型：
--
作者：
CRONENWETT, JL;LINDENAUER, SM
细菌性脓毒症期间不适当的多尿是一个知之甚少的临床实体。本研究采用活铜绿假单胞菌输注来模拟清醒犬的这种疾病。用放射性标记的微球测量肾内血流分布。出现低血压、白细胞减少、血液浓缩、发热、多尿和尿钠排泄。大多数犬显示总肾血流量增加。肾血流从外皮质向髓质皮质重新分布，并增加了髓质皮质的绝对灌注。通过增加血流量对髓质间质浓度梯度的冲洗可以解释所观察到的利尿作用。这些结果支持但不能证明细菌性脓毒症期间肾内血流再分布与多尿之间的因果关系。
Inappropriate polyuria during bacterial sepsis represents a poorly understood clinical entity. This study employed live Pseudomonas aeruginosa infusion to simulate this disorder in awake dogs. Intrarenal blood flow distribution was measured using radioactively labeled microspheres. Hypotension, leukopenia, hemoconcentration, pyrexia, polyuria and natriuresis were produced. Most dogs showed increased total renal blood flow. Redistribution of renal blood flow away from the outer cortex toward the juxtamedullary cortex, and increased absolute perfusion of the juxtamedullary cortex, occurred. Washout of the medullary interstitial concentration gradient by increased blood flow can explain the observed diuresis. These results support but do not prove a causal relationship between redistributed intrarenal blood flow and polyuria during bacterial sepsis.