Cortical Map Reorganization as a Competitive Process
Cortical Map Reorganization as a Competitive Process
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皮质地图重组是一个竞争过程
DOI：
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发表时间：
1994
影响因子：
2.9
通讯作者：
C. L. D'Autrechy
中科院分区：
文献类型：
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作者：
G. Sutton;J. Reggia;S. Armentrout;C. L. D'Autrechy
过去模型的躯体感觉皮层已经成功地证明了地图的形成和随后的地图重组后，局部重复刺激或deafferentation。他们提供了一个令人印象深刻的证明，相当简单的假设皮层连接和突触可塑性可以解释几个观察有关皮层地图。然而，过去的模型没有成功地证明自发地图重组后皮质病变。最近，普遍使用的假设在这些和其他皮质模型，即刺激周抑制是由于水平的皮质内抑制连接，已受到质疑和一个额外的机制，竞争性分布的活动，已被提出。我们实现了一个计算模型的体感皮层的基础上竞争性分布的活动。该模型表现出自发的地图重组响应于皮层病变，经历两个阶段的重组过程。这些结果使一个可测试的预测，可用于实验支持或反驳竞争分布假说的一部分，并可能导致中风后恢复的实际有用的计算模型。
Past models of somatosensory cortex have successfully demonstrated map formation and subsequent map reorganization following localized repetitive stimuli or deafferentation. They provide an impressive demonstration that fairly simple assumptions about cortical connectivity and synaptic plasticity can account for several observations concerning cortical maps. However, past models have not successfully demonstrated spontaneous map reorganization following cortical lesions. Recently, an assumption universally used in these and other cortex models, that peristimulus inhibition is due solely to horizontal intracortical inhibitory connections, has been questioned and an additional mechanism, the competitive distribution of activity, has been proposed. We implemented a computational model of somatosensory cortex based on competitive distribution of activity. This model exhibits spontaneous map reorganization in response to a cortical lesion, going through a two-phase reorganization process. These results make a testable prediction that can be used to experimentally support or refute part of the competitive distribution hypothesis, and may lead to practically useful computational models of recovery following stroke.