Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity
Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity
复制标题
DOI：
10.1093/infdis/jiy221
复制
发表时间：
2018-09-01
影响因子：
6.4
通讯作者：
Marr, Linsey C.
中科院分区：
文献类型：
--
作者：
Kormuth, Karen A.;Lin, Kaisen;Marr, Linsey C.
大流行性和季节性流感病毒可通过气溶胶和飞沫传播，病毒必须在各种环境条件下保持稳定和传染性。采用湿控室，研究了相对湿度对2009年甲型H1N1流感病毒在悬浮气溶胶和静止液滴中稳定性的影响。与湿度调节气溶胶中呼吸道病毒稳定性的流行范式相反，我们发现，在所有相对湿度测试中，补充了分化的原代人气道上皮细胞顶表面物质的病毒在1小时内保持相同的传染性。在细气溶胶和静止液滴中都观察到这种持续的传染性。我们的数据首次表明，流感病毒在相对湿度范围很广的气溶胶中保持高度稳定和传染性。这些结果对了解流感的传播机制及其季节性具有重要意义。
Pandemic and seasonal influenza viruses can be transmitted through aerosols and droplets, in which viruses must remain stable and infectious across a wide range of environmental conditions. Using humidity-controlled chambers, we studied the impact of relative humidity on the stability of 2009 pandemic influenza A(H1N1) virus in suspended aerosols and stationary droplets. Contrary to the prevailing paradigm that humidity modulates the stability of respiratory viruses in aerosols, we found that viruses supplemented with material from the apical surface of differentiated primary human airway epithelial cells remained equally infectious for 1 hour at all relative humidities tested. This sustained infectivity was observed in both fine aerosols and stationary droplets. Our data suggest, for the first time, that influenza viruses remain highly stable and infectious in aerosols across a wide range of relative humidities. These results have significant implications for understanding the mechanisms of transmission of influenza and its seasonality.