An intravascular optical coherence tomography technique for in vivo carotid intima-media thickness measurement and mechanical characterization
An intravascular optical coherence tomography technique for in vivo carotid intima-media thickness measurement and mechanical characterization
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DOI：
10.1016/j.bspc.2023.105936
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发表时间：
2024-04
期刊：
影响因子：
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通讯作者：
Qingyi Guo;Jinlong Chen;Ju Huang;Haofei Liu;Haosen Wang;Cuiru Sun
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文献类型：
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作者：
Qingyi Guo;Jinlong Chen;Ju Huang;Haofei Liu;Haosen Wang;Cuiru Sun
动脉特征参数包括内膜-中膜厚度（IMT）、应变、应变率、弹性模量、顺应性等可能因局部病变生长而分布不均匀。因此，这些参数的全场分布的组合可能比单独的一个更有效地指导血管疾病的诊断和治疗。在这里，我们开发了一种基于血管内相干断层扫描（IVOCT）的全视野测量方法来表征颈动脉在体内的力学特性。提出了基于U-Net模型和质心检测的IMT精确测量图像处理方法。根据中内膜的几何变化得到应变、应变率、增量弹性模量和体积柔度。体外硅胶模体实验表明，基于U-Net方法的血管壁分割精度大于92%，弹性模量测量误差小于2%。应用IVOCTin对猪颈动脉进行活体成像，测量其在心动周期内的IMT和力学特性。该方法有利于研究血管壁的不均匀病理演变，为体内血管力学性能的研究提供了一种有效的测量方法。
Arterial characteristic parameters including the intima-media thickness (IMT), strain, strain rate, elastic modulus, and compliance may be unevenly distributed due to local lesion growth. Thus, a combination of the full-field distribution of these parameters may provide more effective guidance for the diagnosis and treatment of vascular diseases than either one of them. Here, we develop an intravascular coherence tomography (IVOCT) based full-field measurement method to characterize the mechanical properties of carotid arteryin vivo. Image processing methods are proposed based on U-Net model and centroid detection for accurate IMT measurement. The strain, strain rate, incremental elastic modulus and volumetric compliance are obtained based on the geometric changes of intima-media.Ex vivosilica gel phantom tests demonstrate the accuracy of the vascular wall segmentation by the U-Net based method is greater than 92%, and the error for elastic modulus measurement is less than 2%. A porcine carotid artery was imaged by IVOCTin vivo, and the IMT and the mechanical characteristics during cardiac cycle were measured. The proposed method facilitates the study of the uneven pathological evolution of the vascular wall and provides an effective measurement method for the study of vascular mechanical propertiesin vivo.