HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA
HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA
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DOI：
10.1038/314067a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
THEIN, SL
中科院分区：
文献类型：
--
作者：
JEFFREYS, AJ;WILSON, V;THEIN, SL
人类基因组包含许多分散的串联重复的小卫星区域，通过类似于大肠杆菌的广义重组信号（x）的共享10-15个碱基对的核心序列检测。许多小卫星是高度多态性的，这是由于小卫星中重复拷贝数的等位基因变异。基于核心序列的串联重复序列的探针可以同时检测许多高度可变的基因座，并且可以提供在人类遗传分析中普遍使用的个体特异性DNA指纹。
The human genome contains many dispersed tandem-repetitive minisatellite regions detected via a shared 10-15-base pair core sequence similar to the generalized recombinations signal (x) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA fingerprint of general use in human genetic analysis.