The Preventive Effect of Calcium Supplementation on Weak Bones Caused by the Interaction of Exercise and Food Restriction in Young Female Rats During the Period from Acquiring Bone Mass to Maintaining Bone Mass
The Preventive Effect of Calcium Supplementation on Weak Bones Caused by the Interaction of Exercise and Food Restriction in Young Female Rats During the Period from Acquiring Bone Mass to Maintaining Bone Mass
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DOI：
10.1007/s00223-015-0067-5
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Omi, Naomi
中科院分区：
文献类型：
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作者：
Aikawa, Yuki;Agata, Umon;Omi, Naomi
增加钙（Ca）的摄入量对于女性运动员来说很重要，因为她们有因食物摄入不足而导致骨质疏松的风险。以大鼠为实验模型，研究钙补充对青少年女子运动员低骨强度的预防作用。7周龄雌性SD大鼠随机分为4组：安静自由采食组（SED）、自由运动自由采食组（EX）、自由运动限食组（EX-FR）和自由运动限食高钙组（EX-FR+Ca）。对于钙的补充，我们使用1.2%的钙饲料作为“高钙饲料”，其钙含量是正常钙饲料的两倍。实验为期12周。结果，EX-FR组的能量利用率、内脏重量、骨强度、骨矿物质密度和钙吸收显著低于EX组。EX-FR+Ca组的骨强度和Ca吸收显著高于EX-FR组。但EX-FR+Ca组骨强度未达到EX组。这些结果表明，补充钙对骨强度有积极的影响，但这种效果不足以防止年轻女性运动员因食物限制而导致的骨强度降低。
Increasing calcium (Ca) intake is important for female athletes with a risk of weak bone caused by inadequate food intake. The aim of the present study was to examine the preventive effect of Ca supplementation on low bone strength in young female athletes with inadequate food intake, using the rats as an experimental model. Seven-week-old female Sprague-Dawley rats were divided into four groups: the sedentary and ad libitum feeding group (SED), voluntary running exercise and ad libitum feeding group (EX), voluntary running exercise and 30 % food restriction group (EX-FR), and a voluntary running exercise, 30 % food-restricted and high-Ca diet group (EX-FR+Ca). To Ca supplementation, we used 1.2 % Ca diet as "high-Ca diet" that contains two-fold Ca of normal Ca diet. The experiment lasted for 12 weeks. As a result, the energy availability, internal organ weight, bone strength, bone mineral density, and Ca absorption in the EX-FR group were significantly lower than those in the EX group. The bone strength and Ca absorption in the EX-FR+Ca group were significantly higher than those in the EX-FR group. However, the bone strength in the EX-FR+Ca group did not reach that in the EX group. These results suggested that Ca supplementation had a positive effect on bone strength, but the effect was not sufficient to prevent lower bone strength caused by food restriction in young female athletes.