SOLITARY PULMONARY NODULE - HIGH-RESOLUTION CT AND RADIOLOGIC-PATHOLOGICAL CORRELATION
SOLITARY PULMONARY NODULE - HIGH-RESOLUTION CT AND RADIOLOGIC-PATHOLOGICAL CORRELATION
复制标题
DOI：
10.1148/radiology.179.2.2014294
复制
发表时间：
1991-05-01
期刊：
影响因子：
19.7
通讯作者：
MULLER, NL
中科院分区：
文献类型：
--
作者：
ZWIREWICH, CV;VEDAL, S;MULLER, NL
对93例肺结节的高分辨率CT（HRCT）边缘和内部特征进行了分析，并与病理标本进行了对照。 毛刺在病理上与不规则纤维化、肿瘤局部淋巴扩散或浸润性肿瘤生长模式相关，在11个良性结节中观察到6个（55%），在85个恶性结节中观察到74个（87%）。 在3个良性结节（27%）和49个恶性病变（58%）中观察到胸膜标签;病理学上，这些代表纤维化带，通常与非瘢痕性胸膜回缩相关。 在21个恶性病变（25%）和1个良性病变（9%）中观察到结节内低密度的气泡状区域。 它们最常见于细支气管肺泡癌（14例中的7例），并且是由于小支气管通畅或肿瘤腺体内的小囊性空间。 恶性结节比良性结节大（P = 0.02），更常见的表现为毛刺状轮廓（P <0.05）、分叶（P <0.001）和不均匀衰减（P <0.05）。
Edge and internal characteristics of pulmonary nodules evaluated with high-resolution computed tomography (HRCT) were correlated with the pathologic specimens in 93 patients. Spiculation correlated pathologically with irregular fibrosis, localized lymphatic spread of tumor, or an infiltrative tumor growth pattern and was observed in six of 11 benign nodules (55%) and 74 of 85 malignant nodules (87%). Pleural tags were observed in three benign nodules (27%) and 49 malignant lesions (58%); pathologically, these represented fibrotic bands usually associated with juxtacicatricial pleural retraction. Bubblelike areas of low attenuation within the nodule were observed in 21 malignant lesions (25%) and only one benign nodule (9%). They were observed most commonly in bronchioloalveolar carcinomas (seven of 14) and were due either to patent small bronchi or small, cystic spaces within in neoplastic glands. Malignant nodules as a group were larger than benign lesions (P = .02) and more commonly demonstrated a spiculated contour (P < .05), lobulation (P < .001), and inhomogeneous attenuation (P < .05).