The neural mechanisms of re-experiencing physical fatigue sensation: a magnetoencephalography study
The neural mechanisms of re-experiencing physical fatigue sensation: a magnetoencephalography study
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DOI：
10.1007/s00221-016-4648-y
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发表时间：
2016-09-01
影响因子：
2
通讯作者：
Watanabe, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Ishii, Akira;Tanaka, Masaaki;Watanabe, Yasuyoshi
据推测，疲劳感会损害执行活动的能力和效率，并且可能是疲劳本身的原因。因此，弄清疲劳感觉的神经机制是很重要的。精神疲劳感觉的再体验涉及到包括Brodmann区（BA） 40、BA 39和枕核在内的大脑区域。在目前的研究中，我们检查了由重新体验身体疲劳感觉引起的神经活动。15名健康男性志愿者以交叉方式参加了疲劳和控制实验。在疲劳实验中，参与者先进行10分钟的握力任务，以诱发身体疲劳感觉，然后在脑磁图（MEG）过程中重新体验身体疲劳感觉。在对照实验中，他们没有执行握力任务，而是在没有身体疲劳的情况下重新体验了这种感觉。利用脑磁图数据的空间滤波分析来评估与重新体验右手（右状态）、左手（左状态）的身体疲劳感觉相关的神经活动，以及与倾听听觉线索（声音状态）相关的神经活动。包括ba40在内的一些脑区振荡频带功率的变化在左右两种情况下是共同的。在声音条件下，也观察到与重新体验身体疲劳感觉相关的部分神经活动，如ba40中α (8-13 Hz)波段功率的降低。这些发现可能有助于理解有意和无意地重新体验身体疲劳感觉的神经机制。
It has been hypothesized that fatigue sensation impairs the ability and efficiency to perform activities and can be a cause of fatigue itself. As such, it is important to clarify the neural mechanisms of fatigue sensation. The re-experiencing of mental fatigue sensation involves brain regions including Brodmann's area (BA) 40, BA 39, and the pulvinar nucleus. In the present study, we examined neural activity caused by re-experiencing a physical fatigue sensation that had been experienced. Fifteen healthy male volunteers participated in fatigue and control experiments in a crossover fashion. In the fatigue experiment, participants performed a handgrip task for 10 min to induce a physical fatigue sensation and then re-experienced the physical fatigue sensation during magnetoencephalography (MEG) session. In the control experiment, they did not perform the handgrip task but re-experienced the sensation without physical fatigue in an MEG session. Neural activity related to re-experiencing physical fatigue sensations of the right hand (right condition), left hand (left condition), and related to listening to the auditory cues (sound condition) was assessed using spatial filtering analyses of the MEG data. Changes in oscillatory band power in some brain regions, including BA 40, were common between the right and left conditions. A part of the neural activity related to the re-experiencing physical fatigue sensation, such as the decrease in alpha (8-13 Hz) band power in the BA 40, was also observed in the sound condition. These findings may help to understand the neural mechanisms related to intentionally and unintentionally re-experiencing physical fatigue sensation.