Eating disorder symptomatology in major depression
Eating disorder symptomatology in major depression
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DOI：
10.1097/00005053-199703000-00002
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发表时间：
1997-03-01
影响因子：
1.9
通讯作者：
Rosenbaum, JF
中科院分区：
文献类型：
--
作者：
Fava, M;Abraham, M;Rosenbaum, JF
本研究评估了抑郁症门诊患者在抗抑郁治疗前后进食障碍与抑郁症严重程度的关系，并评估了治疗对进食障碍的影响。139例（82例女性和57例男性）重度抑郁症（MDD）门诊患者在氟西汀20 mg/d治疗8周前后填写进食障碍量表（EDI）。MDD和可能的共病饮食障碍的诊断是由DSM-III-R患者版的结构化临床访谈进行的。在基线和终点，几个EDI分量表与抑郁的严重程度显着相关。此外，氟西汀治疗后，所有EDI子量表均显示统计学显著性降低，治疗后抑郁严重程度的变化与EDI贪食症、无效性、完美主义和人际关系困扰子量表评分的变化显著相关。这些结果表明，饮食失调患者的几种特征性症状与抑郁症状的严重程度有关。抗抑郁药治疗后进食障碍的发生率下降可能与抑郁症状的变化有关。
This study evaluated the relationship between eating disorder symptomatology and severity of depression in depressed outpatients before and after antidepressant treatment and assessed the effect of treatment on eating disorder symptomatology. One hundred thirty-nine outpatients (82 women and 57 men) with major depressive disorder (MDD) filled out the eating disorder inventory (EDI) before and after 8 weeks of treatment with fluoxetine 20 mg/day. Diagnoses of MDD and possible comorbid eating disorders were made with the Structured Clinical Interview for DSM-III-R--Patient Edition. Several EDI subscales correlated significantly with severity of depression both at baseline and endpoint. Additionally, all EDI subscales showed a statistically significant decrease following fluoxetine treatment, and changes in depression severity following treatment were significantly related to changes in EDI bulimia, ineffectiveness, perfectionism, and interpersonal distress subscale scores. These results suggest that several symptoms characteristic of eating disordered patients are linked to the severity of depressive symptoms. Decreases in eating disorder symptomatology following antidepressant treatment may be related to changes in depressive symptoms.