An international multicentre study on the allergenic activity of air‐oxidized R‐limonene
An international multicentre study on the allergenic activity of air‐oxidized R‐limonene
复制标题
关于空气氧化 R-柠檬烯致敏活性的国际多中心研究
作者：
Johanna Bråred Christensson;K. Andersen;M. Bruze;J. Johansen;B. García‐Bravo;A. Giménez;C. Goh;R. Nixon;I. White
背景柠檬烯是一种常见的香料萜烯，在其纯形式下，不是过敏性的，或者是一种非常弱的过敏原。然而，柠檬烯在暴露于空气中时会自动氧化，氧化产物会引起接触性过敏。氧化R-柠檬烯先前已在多中心研究中进行斑贴试验，在连续患者中产生2-3%的阳性斑贴试验反应。
Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R‐limonene has previously been patch tested in multicentre studies, giving 2–3% positive patch test reactions in consecutive patients.