SelSim: a program to simulate population genetic data with natural selection and recombination
SelSim: a program to simulate population genetic data with natural selection and recombination
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DOI：
10.1093/bioinformatics/bth417
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发表时间：
2004-12-12
期刊：
影响因子：
5.8
通讯作者：
Coop, G
中科院分区：
文献类型：
--
作者：
Spencer, CCA;Coop, G
SelSim是一个程序，用于Monte Carlo模拟重组区域的DNA多态性数据，其中单个双等位基因位点经历了自然选择。SelSim允许模拟从一个完全随机的模型，或确定性的近似，自然选择的结合框架内。许多不同的突变模型可用于模拟周围的中性变异。该软件包可以详细探索不同的模式和选择的多样性模式的优势的影响。这为经验数据和旨在检测自然选择的方法的统计分析提供了工具。
SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection.