How do temperate bacteriophages affect the fitness of Pseudomonas aeruginosa?
How do temperate bacteriophages affect the fitness of Pseudomonas aeruginosa?
复制标题
温带噬菌体如何影响铜绿假单胞菌的适应度？
DOI：
10.1099/acmi.ac2020.po0441
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发表时间：
2020
影响因子：
--
通讯作者：
Plahe G
中科院分区：
文献类型：
--
作者：
Plahe G
铜绿假单胞菌的利物浦流行株（LES）是一种关键的机会致病菌，也是囊性纤维化（CF）患者死亡和发病的主要原因。它已经建立在其基因组中携带独特的前噬菌体，通过水平基因转移为宿主细菌提供优势。几个著名的伙伴关系之间的原噬菌体和它们的细菌宿主的特点，但是，很少有人知道其他噬菌体宿主系统。该项目探讨了铜绿假单胞菌PAO1及其噬菌体之间的动力学，确定它们是否在CF肺中具有优势。
The Liverpool Epidemic Strain(LES) of Pseudomonas aeruginosa is a key opportunistic bacterium and a major cause of mortality and morbidity in cystic fibrosis (CF) patients. It has been established to carry distinctive prophages within its genome, providing the host bacterium with advantages through horizontal gene transfer. Several well-known partnerships between prophage and their bacterial hosts have been characterised, however, very little is known about other phage-host systems. This project explores the dynamics between Pseudomonas aeruginosa PAO1 and its phage, determining whether they confer an advantage in the CF lung.