Short Communication: Manα1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope.
Short Communication: Manα1-2Man-Binding Anti-HIV Lectins Enhance the Exposure of V2i and V3 Crown Neutralization Epitopes on the V1/V2 and V3 Hypervariable Loops of HIV-1 Envelope.
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简短的交流：Manα1-2Man 结合抗 HIV 凝集素增强 HIV-1 包膜 V1/V2 和 V3 高变环上 V2i 和 V3 冠中和表位的暴露。
DOI：
10.1089/aid.2016.0262
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发表时间：
2017
影响因子：
1.5
通讯作者：
Arora,SunilK
中科院分区：
文献类型：
--
作者：
Jan,Muzafar;Upadhyay,Chitra;Sharma,Aman;Hioe,CatarinaE;Arora,SunilK
This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env. Using lectins specific to Manα1-2Man residue containing Man6-9GlcNAc2glycans extensively decorating HIV-1 Env, we found that Manα1-2Man-binding lectins enhance the exposure of these partially and transiently exposed epitopes and consequentially increase the neutralization strength of antibodies against these epitopes.
