Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion
Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion
复制标题
DOI：
10.1097/00004647-199611000-00036
复制
发表时间：
1996-11-01
影响因子：
6.3
通讯作者：
delZoppo, GJ
中科院分区：
文献类型：
--
作者：
Hamann, GF;Okada, Y;delZoppo, GJ
脑缺血后的出血性转化是众所周知的临床问题。用层粘连蛋白抗原标记的完整基底板(BL)在幼年雄性狒狒大脑中动脉闭塞(MCA：O)和再灌流3h后出血区和非出血区(MCA：O)的出现频率进行了评估。再灌流24小时前未检测到实质血红蛋白。出血区的层粘连蛋白密度(6.2+/-2.4)显著低于非缺血区(10.5+/-2.4)(p<；0.05)和非缺血区基底节(17.0+/-2.7)(p<；0.01)。血液完整性随时间的变化似乎与血液成分的外渗有关。
Hemorrhagic transformation after cerebral ischemia is a well known clinical concern. The frequency of intact basal lamina (BL), identified by laminin antigen, in hemorrhagic and nonhemorrhagic zones after middle cerebral artery occlusion (MCA:O) and 3-h MCA:O with reperfusion in adolescent male baboons was assessed. Parenchymal hemoglobin was not detected prior to 24-h reperfusion. A significant decrease in the density of laminin (BL) in hemorrhagic zones (6.2 +/- 2.4) compared with nonhemorrhagic ischemic zones (10.5 +/- 2.4) (p < 0.05) and nonischemic basal ganglia (17.0 +/- 2.7) (p < 0.01) was observed. Time-dependent changes in BL integrity appear linked to the extravasation of blood components.