Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes.
Anti-inflammatory Approaches to Mitigate the Neuroinflammatory Response to Brain-Dwelling Intracortical Microelectrodes.
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DOI：
10.29245/2578-3009/2018/4.1157
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Capadona, Jeffrey R
中科院分区：
文献类型：
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作者：
Bedell, Hillary W;Capadona, Jeffrey R
皮层内微电极既用于基础研究，以增加我们对神经系统的了解，也用于通过脑机接口实现康复目的。然而，阻碍这项技术广泛临床应用的挑战依然存在。一个主要的挑战是对皮质内微电极的神经炎症反应。这篇小综述详细介绍了用于减少这些设备的炎症反应的免疫调节策略。随着时间的推移，广谱抗炎方法，如地塞米松和米诺环素，演变成更有针对性的治疗，因为神经炎症的潜在生物学被阐明。这篇综述还介绍了未来免疫调节靶向研究的新目标。
Intracortical microelectrodes are used both in basic research to increase our understanding of the nervous system and for rehabilitation purposes through brain-computer interfaces. Yet, challenges exist preventing the widespread clinical use of this technology. A prime challenge is with the neuroinflammatory response to intracortical microelectrodes. This mini-review details immunomodulatory strategies employed to decrease the inflammatory response to these devices. Over time, broad-spectrum anti-inflammatory approaches, such as dexamethasone and minocycline, evolved into more targeted treatments since the underlying biology of the neuroinflammation was elucidated. This review also presents studies which examine novel prospective targets for future immunomodulatory targeting.