Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat.
Opioid receptor subtypes that mediate a microwave-induced decrease in central cholinergic activity in the rat.
复制标题
阿片受体亚型介导微波诱导的大鼠中枢胆碱能活性降低。
DOI：
10.1002/bem.2250130308
复制
发表时间：
1992
影响因子：
1.9
通讯作者：
Guy,AW
中科院分区：
文献类型：
--
作者：
Lai,H;Carino,MA;Horita,A;Guy,AW
We performed experiments to investigate subtypes of opioid receptors in the brain involved in the effect of acute (45 min) pulsed microwave exposure (2,450‐MHz, 2‐μs pulses, 500 pps, average power density 1 mW/cm2, peak‐power density, 1 W/cm2, average whole body SAR 0.6 W/kg) on cholinergic activity in the rat brain. Rats were pretreated by microinjection of specific antagonists of μ, δ, and κ opioid‐receptors into the lateral cerebroventricle before exposure to microwaves. The data showed that all three subtypes of opioid receptors are involved in the microwave‐induced decrease in cholinergic activity in the hippocampus. However, the microwave‐induced decrease in cholinergic activity in the frontal cortex was not significantly affected by any of the drug treatments, confirming our previous conclusion that the effect of microwaves on the frontal cortex is not mediated by endogenous opioids. © 1992 Wiley‐Liss, Inc.
