TREATMENT OF IMMATURE AND MATURE FASCIOLA-HEPATICA INFECTIONS IN SHEEP WITH TRICLABENDAZOLE
TREATMENT OF IMMATURE AND MATURE FASCIOLA-HEPATICA INFECTIONS IN SHEEP WITH TRICLABENDAZOLE
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DOI：
10.1136/vr.113.14.315
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发表时间：
1983-01-01
影响因子：
2.2
通讯作者：
SARASIN, G
中科院分区：
文献类型：
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作者：
BORAY, JC;CROWFOOT, PD;SARASIN, G
当以2.5 mg/kg体重给药时，三氯苯达唑（CGA 89317）对8周龄和12周龄F的有效率分别为89.9%和98.1%。感染绵羊的肝脏。在5 mg/kg剂量下，对4周龄和8周龄吸虫的有效性分别为91.7%和98.3%，对12周龄吸虫的有效性为100%。在10 mg/kg剂量下，对1周龄吸虫（2组绵羊）的有效性为92.8%和97.8%，对2周龄或4周龄吸虫的有效性≥ 99.2%，对6周龄吸虫的有效性为100%。如果剂量增加到15 mg/kg，药物消除了98.0%的一日龄吸虫。三氯苯达唑是同样有效的，当口服或通过腔内或皱胃内注射。最大耐受剂量为200 mg/kg。
When given at 2.5 mg/kg body-weight, triclabendazole (CGA 89317) was 89.9 and 98.1% effective against 8- and 12-week-oldF. hepaticarespectively in experimentally infected sheep. At 5 mg/kg it was 91.7 and 98.3% effective against 4- and 8-week-old flukes and 100% against 12-week-old flukes. At 10 mg/kg it was 92.8 and 97.8% effective against one-week-old flukes (2 groups of sheep), ≥ 99.2% against 2- or 4-week-old flukes and 100% against 6-week-old flukes. If the dose was raised to 15 mg/kg the drug eliminated 98.0% of one-day-old flukes. Triclabendazole was equally efficient when administered orally or by intraruminal or intra-abomasal injection. The maximum tolerated dose was 200 mg/kg.