Exercise mimetics: harnessing the therapeutic effects of physical activity
Exercise mimetics: harnessing the therapeutic effects of physical activity
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DOI：
10.1038/s41573-021-00217-1
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发表时间：
2021-06-08
影响因子：
120.1
通讯作者：
Hannan, Anthony J.
中科院分区：
文献类型：
--
作者：
Gubert, Carolina;Hannan, Anthony J.
体育活动已证明在预防和改善广泛的疾病，特别是中枢神经系统疾病方面具有积极作用。因此，在治疗上模仿运动效果的策略越来越受到关注。在这里，Gubert和Hannan专注于身体活动在中枢神经系统中的分子和细胞效应，评估治疗性运动模拟物的发展机会。运动模拟物是一类提出的治疗方法，专门模拟或增强运动的治疗效果。增加身体活动已证明对预防和改善多种疾病有积极作用，包括阿尔茨海默病和痴呆症等脑部疾病、癌症、糖尿病和心血管疾病。本文讨论了与身体活动的有益影响相关的分子机制和信号通路，重点是对大脑功能和认知增强的影响。新兴的治疗目标和战略的发展运动模拟，特别是在中枢神经系统疾病领域，以及相关的机遇和挑战，进行了讨论。
Physical activity has demonstrated positive effects in preventing and ameliorating a broad range of diseases, particularly central nervous system disorders. Accordingly, strategies to therapeutically mimic the effects of exercise are gaining interest. Here, Gubert and Hannan focus on the molecular and cellular effects of physical activity in the central nervous system, assessing opportunities for the development of therapeutic exercise mimetics.Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance the therapeutic effects of exercise. Increased physical activity has demonstrated positive effects in preventing and ameliorating a wide range of diseases, including brain disorders such as Alzheimer disease and dementia, cancer, diabetes and cardiovascular disease. This article discusses the molecular mechanisms and signalling pathways associated with the beneficial effects of physical activity, focusing on effects on brain function and cognitive enhancement. Emerging therapeutic targets and strategies for the development of exercise mimetics, particularly in the field of central nervous system disorders, as well as the associated opportunities and challenges, are discussed.