Insensitivity to salt of assembly of a rigid biopolymer aggrecan.
Insensitivity to salt of assembly of a rigid biopolymer aggrecan.
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DOI：
10.1103/physrevlett.101.068301
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发表时间：
2008-08-08
影响因子：
8.6
通讯作者：
Geissler E
中科院分区：
文献类型：
--
作者：
Horkay F;Basser PJ;Hecht AM;Geissler E
许多聚电解质，从磺化聚苯乙烯到DNA，它们的相行为对盐浓度表现出很强的敏感性，特别是对高价盐，这往往导致相分离。我们发现，僵硬的hagaggrecan表现出质的不同的行为。具体来说，聚集蛋白聚糖溶液的散射特性对钙盐的添加特别不敏感，赋予聚集蛋白聚糖离子库的作用，介导软骨和骨骼中的钙代谢，并且还提供对压缩载荷的渗透弹性。
Many polyelectrolytes, ranging from sulfonated polystyrene to DNA, exhibit a strong sensitivity of their phase behavior to salt concentration, especially to higher valence salts, which often lead to phase separation. We show that the stiff polyelectrolyte aggrecan exhibits a qualitatively different behavior. Specifically, the scattering properties of aggrecan solutions are exceptionally insensitive to the addition of calcium salt, conferring on aggrecan the role of an ion reservoir mediating calcium metabolism in cartilage and bone, and also providing osmotic resilience to compressive load.