Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study.
Trends in Renal-Cell Carcinoma Incidence and Mortality in the United States in the Last 2 Decades: A SEER-Based Study.
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DOI：
10.1016/j.clgc.2018.10.002
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发表时间：
2019-03
影响因子：
3.2
通讯作者：
Ho TH
中科院分区：
文献类型：
--
作者：
Saad AM;Gad MM;Al-Husseini MJ;Ruhban IA;Sonbol MB;Ho TH
肾细胞癌是美国常见的恶性肿瘤之一。由于多种原因，肾癌的发病率和死亡率一直在变化。我们使用监测、流行病学和最终结果(SEER)数据库对美国肾细胞癌的发病率和死亡率趋势进行了彻底的调查。对1992至2015年间诊断的肾癌病例访问了SEER 13个登记处。根据人口学和肿瘤特征计算发病率和死亡率。我们计算了这些比率的年度百分比变化(APC)。比率以10万人年表示。总共审查了104,584例肾细胞癌病例，其中47,561例死亡。总发病率为11.281/10万人年。发病率每年增加2.421%(95%CI，2.096-2.747，p<；.001)，但后来自2008年以来趋于稳定。然而，透明细胞亚型的发生率继续上升(1.449%；95%CI，0.216-2.697，P=.024)。自2001年以来，RCC的总死亡率一直在下降。然而，与远距离肾癌相关的死亡率直到2012年才开始下降，−为18.270%(−28.775-6.215，P=0.006)。尽管肾癌发病率总体上有所上升，但近期肾癌发病率一直处于平稳状态，死亡率显著下降。由于多种原因，肾细胞癌(RCC)的发病率和死亡率一直在变化。我们使用SEER审查了1992至2015年间确诊的104,584例肾癌病例，其中47,561例死亡。尽管肾癌的发病率总体上有所增加，但最近肾癌发病率一直处于平稳状态，死亡率显著下降。
Renal cell carcinoma (RCC) is one of the common malignancies in the United States. RCC incidence and mortality have been changing due to many reasons. We provide a thorough investigation of incidence and mortality trends of RCC in the US using the surveillance, epidemiology and end results (SEER) database. The SEER 13 registries were accessed for RCC cases diagnosed between 1992 and 2015. Incidence and mortality were calculated by demographic and tumor characteristics. We calculated annual percent changes (APC) of these rates. Rates were expressed by 100,000 person-years. A total of 104,584 RCC cases were reviewed with 47,561 deaths. The overall incidence was 11.281 per 100,000 person-years. Incidence increased by 2.421% per year (95% CI, 2.096-2.747, p<.001) but later became stable since 2008. However, the incidence of clear-cell subtype continued to increase (1.449%; 95% CI, 0.216-2.697, P=.024). RCC overall mortality rates have been declining since 2001. However, mortality associated with distant RCC only started to decrease in 2012 with APC of −18.270% (−28.775- -6.215, P = .006) Despite an overall increase in the incidence of RCC, there has been a recent plateau in RCC incidence rates with a significant decrease in mortality. Renal Cell Carcinoma (RCC) incidence and mortality have been changing due to many reasons. We used SEER to review 104,584 RCC cases with 47,561 deaths diagnosed between 1992 and 2015. Despite an overall increase in the incidence of RCC, there has been a recent plateau in RCC incidence rates with a significant decrease in mortality.
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