Carbon dots for the treatment of cancer-related anemia.
Carbon dots for the treatment of cancer-related anemia.
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DOI：
10.1097/bs9.0000000000000120
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发表时间：
2022-07
期刊：
影响因子：
1
通讯作者：
Ji, Peng
中科院分区：
文献类型：
--
作者：
Han, Xu;Ji, Peng
红细胞生成是造血干细胞（hsc）分化、增殖并最终形成成熟红细胞的过程。1 .红细胞生成的早期阶段涉及HSC对红系祖细胞的承诺，包括爆发形成单位-红系（BFU-E）和集落形成单位-红系（CFU-E）。随后是末梢红细胞生成，形态学上可识别的红母细胞增殖并分化为去核红细胞。每一个步骤都是由一个高度复杂的监管网络协调的。这一网络的任何组成部分的破坏都会导致各种红细胞相关疾病，主要表现为贫血。贫血是世界范围内的一个主要公共卫生问题。原发性贫血通常由造血系统异常引起，继发性贫血可由癌症等慢性疾病引起。6-9癌症相关性贫血是一种常见疾病，根据癌症类型和疾病阶段的不同，患病率为30%至90%。10 .贫血会显著降低癌症患者的生活质量，缩短生存期。8
Erythropoiesis is the process in which hematopoietic stem cells (HSCs) differentiate, proliferate, and eventually form mature red blood cells. 1 The early phase of erythropoiesis involves HSC commitment to erythroid progenitors including burst-forming unit-erythroid (BFU-E) and colony forming unit-erythroid (CFU-E). This is followed by terminal erythropoiesis in which morphologically recognizable erythroblasts proliferate and differentiate to enucleated red blood cells. 2, 3 Each of these steps is coordinated by a highly complex regulatory network. Disruption of any component of this network leads to a variety of erythroid-related disorders, manifested mainly as anemia. 4Anemia is a major public health problem worldwide. 5 While primary anemia is usually caused by abnormalities in the hematopoietic system, secondary anemia can be induced by chronic diseases such as cancers. 6–9 Cancer-related anemia is a common condition with prevalence of 30% to 90% depending on cancer types and the disease stage. 10 Anemia significantly reduces the quality of life and shortens survival in cancer patients. 8