Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example.
Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines--Flos Lonicerae Japonicae--Fructus Forsythiae Herb Couples as an Example.
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DOI：
10.3390/ijms161226132
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发表时间：
2015-12-04
影响因子：
5.6
通讯作者：
Di L
中科院分区：
文献类型：
--
作者：
Zhou W;Cai B;Shan J;Wang S;Di L
中医药因其悠久的保健和疾病控制历史而受到世界各国的广泛关注，中药制剂或专利药物的内化被认为是中医药现代化进程中的风向标。然而，中药中多组分的多靶点效应不仅阻碍了质量评价体系(生物利用度)的构建，也阻碍了药物技术的应用，导致临床疗效不佳。本文就如何识别中药制剂中的标志物成分，建立生物利用度评价体系，提高中药制剂的生物利用度进行了文献综述和思考。我们预计，目前的研究将是积极和有益的。
Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative.