The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus.
The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus.
复制标题
2型糖尿病中性粒细胞与淋巴细胞比值与周围神经病变的关系
DOI：
10.1097/md.0000000000008289
复制
发表时间：
2017-11
期刊：
影响因子：
1.6
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Xu T;Weng Z;Pei C;Yu S;Chen Y;Guo W;Wang X;Luo P;Sun J
摘要探讨2型糖尿病患者中性粒细胞与淋巴细胞比值（NLR）与糖尿病周围神经病变（DPN）的关系。新诊断的2型糖尿病（T2DM）患者共557例，其中无并发症T2DM患者397例（DM组），T2DM合并DPN患者160例（DPN组）。学生t检验，Mann-Whitney U检验，或&khgr；对两组患者的中性粒细胞、淋巴细胞水平及外周血NLR等生化指标进行2检验；采用Pearson相关分析计算NLR与检测因子的相关性；通过logistic回归分析和多因素分析估计DPN的危险因素。DPN组甘油三酯（TG）、中性粒细胞、空腹胰岛素、尿白蛋白、2小时后葡萄糖值均显著高于DM组，淋巴细胞数量显著低于DM组（P < 0.05）。05);DPN组NLR值显著高于DM组（2.58±0.50 vs 2.18±0.61,P < 0.001）；logistic回归分析显示NLR (P =。002, OR = 4.960, 95% CI = 1.843-13.349)是DPN的危险因素。多因素logistic回归分析显示DPN与NLR独立相关(P =。002, or = 4.960, 95% ci = 1.843-13.349)。ROC曲线分析证实NLR诊断DPN的最佳截断点、特异性和敏感性分别为2.13%、48.1%和81.3%。我们的结果显示NLR与DPN显著相关，提示NLR可能是DPN的独立危险因素。
Abstract To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus. A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann–Whitney U test, or &khgr;2 test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis. The values of triglyceride (TG), neutrophils, fasting insulin, urinary albumin, and 2 hour postglucose in DPN group were significantly higher than those of the DM group, whereas the number of lymphocytes of DPN group was considerably lower than that of the DM group (P < .05 respectively); NLR values were remarkably higher in DPN group compared with those of DM group (2.58 ± 0.50 vs 2.18 ± 0.61, P < .001); logistic regression analysis showed that NLR (P = .002, OR = 4.960, 95% CI = 1.843–13.349) was a risk factor of DPN. Multivariate logistic regression analysis showed that DPN was independently related to NLR (P = .002, OR = 4.960, 95% CI = 1.843–13.349). The ROC curve analysis confirmed that the optimal cut-off point, specificity, and sensitivity in diagnosing DPN by NLR were 2.13%, 48.1%, and 81.3% respectively. Our results showed that NLR is significantly correlated with DPN, which suggested that NLR may be an independent risk factor of DPN.