EPIDEMIOLOGIC EVIDENCE REGARDING PREDISPOSING FACTORS TO PROSTATE-CANCER
EPIDEMIOLOGIC EVIDENCE REGARDING PREDISPOSING FACTORS TO PROSTATE-CANCER
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DOI：
10.1002/pros.2990160302
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发表时间：
1990-01-01
期刊：
影响因子：
2.8
通讯作者：
ISAACS, JT
中科院分区：
文献类型：
--
作者：
CARTER, BS;CARTER, HB;ISAACS, JT
1990年，前列腺癌将成为美国男性中诊断出的最常见癌症，并且将成为这些男性癌症死亡的第二大原因。十分之一的美国男性在其一生中会患上前列腺癌。每年有两万例前列腺癌发生在65岁以下的男性中。死于前列腺癌的男性平均寿命损失为9年。此外，前列腺癌的发病率和死亡率都在增加。根据最近的研究检查这种疾病的可能诱发因素，对关于前列腺癌的文献进行回顾是及时的。在这篇评论中，一个框架，了解遗传和环境因素，可能易患前列腺癌。识别临床前列腺癌的易感因素提供了降低美国前列腺癌发病率和死亡率的可能性。流行病学证据有关可能的诱发因素前列腺癌的审查。
In 1990, prostate cancer will be the most common cancer diagnosed in U.S. men and will be the second‐leading cause of cancer mortality in these men. One in ten U.S. men will develop prostate cancer in his lifetime. Twenty thousand prostate cancer cases occur each year in men under the age of 65. The average number of years of life lost for a man dying of prostate cancer is nine. In addition, both incidence and mortality of prostate cancer are increasing. A review of the literature regarding prostate cancer is timely in light of recent studies examining possible predisposing factors for this disease. In this review, a framework for understanding genetic and environmental factors which may predispose to prostate cancer is presented. The identification of factors which predispose to clinical prostate cancer offers the possibility of lowering the incidence and mortality of prostate cancer in the United States. Epidemiologic evidence regarding possible predisposing factors to prostate cancer is reviewed.