Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak
Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak
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DOI：
10.1016/j.jasms.2007.11.001
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Melchiorre, Nunzia
中科院分区：
文献类型：
--
作者：
Ciminiello, Patrizia;Dell'Aversano, Carmela;Melchiorre, Nunzia
在本文中，我们报告了对 2006 年夏季利古里亚海岸采集的浮游生物样本进行的液相色谱串联质谱 (LC-MS) 调查，当时正值热带微藻 Ostreopsis ovata 大量繁殖。 LC-MS 分析表明存在推定的海龟毒素以及迄今为止从未报道过的更丰富的海龟毒素样化合物，我们将其命名为 ovatoxin-a。根据分子式、裂解模式和色谱行为，卵毒素-a 的结构似乎与海藻毒素的结构严格相关。我们还报告了对培养的 O. ovata 的分析，这对于明确证明田间样品中包含的推定的水苋毒素和卵毒素-a 实际上是由 O. ovata 本身产生的。
In this article we report on the liquid chromatography tandem mass spectrometry (LC-MS) investigation of plankton samples collected in the summer of 2006 along the Ligurian coasts, coinciding with a massive bloom of the tropical microalga Ostreopsis ovata. LC-MS analyses indicated the occurrence of putative palytoxin along with a much more abundant palytoxin-like compound never reported so far, which we named ovatoxin-a. On the basis of molecular formula, fragmentation pattern, and chromatographic behavior, the structure of ovatoxin-a appeared to be strictly related to that of palytoxin. We report also on the analysis of cultured O. ovata, which was necessary to unequivocally demonstrate that putative palytoxin and ovatoxin-a contained in field samples were actually produced by O. ovata itself.