The impact of the lockdown and the re-opening of schools and day cares on the epidemiology of SARS-CoV-2 and other respiratory infections in children - A nationwide register study in Finland.
The impact of the lockdown and the re-opening of schools and day cares on the epidemiology of SARS-CoV-2 and other respiratory infections in children - A nationwide register study in Finland.
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DOI：
10.1016/j.eclinm.2021.100807
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发表时间：
2021-04
影响因子：
15.1
通讯作者：
Kuitunen I
中科院分区：
文献类型：
--
作者：
Haapanen M;Renko M;Artama M;Kuitunen I
芬兰于3月开始实施全国范围的限制措施，以防止COVID-19的传播，导致学校和日托中心关闭。本研究的目的是描述关闭和重新开放对呼吸道病原体流行病学的影响。2017-2020年期间，从国家传染病登记处收集了经证实的SARS-CoV-2;呼吸道合胞病毒（RSV）;流感（A & B）;副流感病毒、腺病毒和鼻病毒;肺炎支原体和肺炎链球菌的儿童病例。计算2020年每10万名儿童的每周发病率（第1至35周）及其95%置信区间（CI），并按发病率比（IRR）与2017 - 2019年的相应时期进行比较。封锁对除SARS-CoV-2以外的呼吸道病原体的发病率产生了直接影响。封锁开始后一周的IRR为0·3（CI 0·3-0·4），下周的IRR为0·1（0·1-0·2）。SARS-CoV-2的发病率在封锁开始八周后开始下降。SARS-CoV-2的最高周发病率为7·2/10万儿童。封锁的影响一直持续到夏末。鼻病毒和SARS-CoV-2在8月份学校或日托所开放之前开始增加。学校的重新开放似乎对任何病原体的发病率没有影响。我们的研究结果表明，一般的社会距离，包括学校和日托关闭，在减少感染方面发挥了至关重要的作用，并且这种影响持续了几个星期。学校和日托中心的重新开放似乎没有对任何呼吸道病原体的发病率产生直接影响。这项研究没有资金来源。
Nationwide restrictions started in Finland in March to prevent the spread of COVID-19, leading to school and day care closures. The aim of this study is to describe the effect of closures and re-openings on the respiratory pathogen epidemiology. Laboratory-confirmed cases of SARS-CoV-2; respiratory syncytial virus (RSV); influenza (A & B); parainfluenza-, adeno-, and rhinoviruses; Mycoplasma pneumoniae; and Streptococcus pneumoniae in children were collected from the National Infectious Disease Register over the period of 2017–2020. Weekly incidences (weeks 1 to 35) with 95% confidence intervals (CIs) were calculated per 100 000 children in 2020 and compared by incidence rate ratios (IRRs) to corresponding periods in 2017−2019. The lockdown had immediate impact on the incidences of respiratory pathogens except SARS-CoV-2. Week after the lockdown began IRR was 0•3 (CI 0•3–0•4) and next week the IRR was 0•1 (0•1–0•2). The incidence of SARS-CoV-2 started to decline eight weeks after the lockdown began. The highest recorded weekly incidence of SARS-CoV-2 was 7•2/100 000 children. The effect of the lockdown lasted until late summer. Rhinovirus and SARS-CoV-2 began to increase before the schools or day cares opened in August. The re-opening of schools seemed to have no impact on the incidence of any pathogen. Our results suggest that general social distancing, including school and day care closures, played a crucial role in reducing infections, and the effect lasted for several weeks. The re-opening of schools and day care centres seems to have had no immediate impact on the incidences of any respiratory pathogens. This study had no funding source.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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影响因子：
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作者：
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DOI：
10.1016/s1473-3099(20)30785-4
发表时间：
2021-03
期刊：
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影响因子：
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作者：
Li Y;Campbell H;Kulkarni D;Harpur A;Nundy M;Wang X;Nair H;Usher Network for COVID-19 Evidence Reviews (UNCOVER) group
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Usher Network for COVID-19 Evidence Reviews (UNCOVER) group