Novelty seeking and introversion do not predict the long-term risk of Parkinson disease
Novelty seeking and introversion do not predict the long-term risk of Parkinson disease
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DOI：
10.1212/wnl.0b013e3181ea15fd
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发表时间：
2010-07-27
期刊：
影响因子：
9.9
通讯作者：
Rocca, W. A.
中科院分区：
文献类型：
--
作者：
Arabia, G.;Grossardt, B. R.;Rocca, W. A.
目的：帕金森病（PD）患者可能具有特征性的病前人格。我们通过长期随访的大型历史队列研究验证了这一假设。方法：我们在该地区进行了一项历史队列研究，包括以明尼苏达州罗切斯特为中心的120英里半径。我们从1962年到1965年在梅奥诊所招募了7216名受试者，他们完成了明尼苏达多相人格量表（MMPI）的研究，我们考虑了5种MMPI量表来测量感觉寻求、轻躁狂、积极情绪、社会内向和约束。总共6822名受试者（占基线样本的94.5%）被跟踪了40多年，有的是主动的（通过访谈和检查），有的是被动的（通过医疗记录）。结果：随访期间发生帕金森病227例（PD 156例）。我们选择的3个MMPI量表来测量外向人格结构（感觉寻求、轻躁狂和积极情绪）并没有显示出更高的分数与PD风险降低相关的预期模式。同样，我们选择用于测量内向人格结构（社会内向和约束）的2个MMPI量表并没有显示出更高的分数与PD风险增加相关的预期模式。然而，较高的约束评分与所有类型帕金森病的风险增加相关（风险比1.39;95% CI 1.06-1.84; p = 0.02）。结论：我们认为与内向和外向相关的人格特征不能预测PD的风险。神经病学(R) 2010；75:349 - 357
Objective: It has been suggested that people who develop Parkinson disease (PD) may have a characteristic premorbid personality. We tested this hypothesis using a large historical cohort study with long follow-up.Methods: We conducted a historical cohort study in the region including the 120-mile radius centered in Rochester, MN. We recruited 7,216 subjects who completed the Minnesota Multiphasic Personality Inventory (MMPI) for research at the Mayo Clinic from 1962 through 1965 and we considered 5 MMPI scales to measure sensation seeking, hypomania, positive emotionality, social introversion, and constraint. A total of 6,822 subjects (94.5% of the baseline sample) were followed over 4 decades either actively (via interview and examination) or passively (via medical records).Results: During follow-up, 227 subjects developed parkinsonism (156 developed PD). The 3 MMPI scales that we selected to measure the extroverted personality construct (sensation seeking, hypomania, and positive emotionality) did not show the expected pattern of higher scores associated with reduced risk of PD. Similarly, the 2 MMPI scales that we selected to measure the introverted personality construct (social introversion and constraint) did not show the expected pattern of higher scores associated with increased risk of PD. However, higher scores for constraint were associated with an increased risk of all types of parkinsonism pooled together (hazard ratio 1.39; 95% CI 1.06-1.84; p = 0.02).Conclusions: We suggest that personality traits related to introversion and extroversion do not predict the risk of PD. Neurology (R) 2010;75:349-357