Inhibition of Attention for Affective Material: Contributions by HOMER1 Gene Variation.
Inhibition of Attention for Affective Material: Contributions by HOMER1 Gene Variation.
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DOI：
10.1037/pne0000027
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发表时间：
2015-12
影响因子：
--
通讯作者：
Beevers CG
中科院分区：
文献类型：
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作者：
Wells TT;Judah MR;Ellis AJ;McGeary JE;Beevers CG
未能抑制对不相关情感信息的关注与抑郁和沉思有关。然而，很少有研究调查这一过程的生物学基础。一项全基因组关联研究发现 HOMER1 基因的变异与重度抑郁症有关，并且与执行功能低下有关。一些研究已将 BDNF 基因的变异与反刍等情绪和认知过程联系起来。目前的研究检查了这两种吉祥基因变异与情感信息注意力抑制之间的关联。在研究 1 中，60 名精神健康的社区参与者用积极和消极的词语完成了消极情感启动任务。 HOMER1 变异（而非 BDNF 变异）与难以抑制不相关的负面信息相关。这些结果在第二项研究中得到了重复，该研究使用了 97 名精神健康的年轻人作为样本。讨论了对当前文献和未来方向的影响。
Failure to inhibit attention to irrelevant affective information has been linked to depression and rumination. However, few studies have investigated the biological bases of this process. Variation in the HOMER1 gene was identified in a genome-wide association study as associated with major depressive disorder and is associated with executive functioning inefficiency. Several studies have linked variation in the BDNF gene with emotional and cognitive processes such as rumination. The current study examined the association between these two auspicious genetic variants and inhibition of attention for affective information. In Study 1, 60 psychiatrically healthy community participants completed a negative affective priming task with positive and negative words. HOMER1 variation, but not BDNF variation, was associated with difficulty inhibiting irrelevant negative information. These results were replicated in a second study utilizing a sample of 97 psychiatrically healthy young adults. Implications for the current literature and future directions are discussed.