Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.
Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes.
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DOI：
10.1186/1746-1596-8-129
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发表时间：
2013-08-02
影响因子：
2.6
通讯作者：
Zhou G
中科院分区：
文献类型：
--
作者：
Cheng H;Qin Y;Fan H;Su P;Zhang X;Zhang H;Zhou G
辅激活子相关精氨酸甲基转移酶1（CARM 1）属于蛋白质精氨酸甲基转移酶家族。据报道，CARM 1与乳腺癌中的高级别肿瘤相关。CARM 1在乳腺癌中的表达模式及其与临床病理特征和分子亚型的关系尚不清楚。收集了247例浸润性乳腺癌病例，并准备用于组织阵列。其中37例肿瘤周围有良性腺上皮。采用免疫组织化学方法研究分子亚型和CARM 1表达。在细胞质和/或细胞核中观察到细胞染色。与邻近良性上皮相比，腺癌中CARM 1的染色显著更强。CARM 1过表达与年轻、高分级、雌激素受体（ER）和孕激素受体（PR）阴性、p53表达增加、Ki-67指数高有显著相关性。我们的研究表明CARM 1过表达与HER 2蛋白表达的增加相关。此外，我们的数据显示CARM 1在HER 2亚型（69.6%）、管腔B亚型（59.6%）和TN亚型（57.1%）中的过表达率显著高于管腔A亚型（41.3%）。浸润性乳腺癌中CARM 1表达增加。CARM 1过表达与临床病理参数特征不佳和HER 2过表达相关。不同分子亚型与CARM 1过表达的关系存在显著差异。我们的研究结果支持使用CARM 1在乳腺癌患者预后分层中的价值及其在靶向治疗中的潜在治疗意义。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/4116338491022965
Coactivator-associated arginine methyltransferase 1 (CARM1) belongs to the protein arginine methyltransferase family. CARM1 has been reported to be associated with high grade tumors in breast cancer. It still remains unknown the expression pattern of CARM1 in breast cancer and its relationships with clinicopathological characteristics and molecular subtypes. Two hundred forty-seven invasive breast cancer cases were collected and prepared for tissue array. There were thirty-seven tumors with benign glandular epithelium adjacent to the tumors among these cases. Molecular subtype and CARM1 expression were investigated using immunohistochemistry. Cell staining was observed in the cytoplasm and/or nucleus. Staining for CARM1 was significantly stronger in adenocarcinoma compared with adjacent benign epithelium. There is a significant correlation between CARM1 overexpression with young age, high grade, estrogen receptor (ER) and progesterone receptor (PR) negative, increased p53 expression, and high Ki-67 index. Our study demonstrated CARM1 overexpression was associated with an increase in the protein expression of HER2. Furthermore, our data indicated CARM1-overexpression rate were remarkably higher in HER2 subtype (69.6%), luminal B subtype (59.6%) and TN subtype (57.1%) compared with luminal A subtype (41.3%). CARM1 expression was increased in invasive breast cancer. CARM1 overexpression was associated with poorly characterized clinicopathologic parameters and HER2 overexpression. There were significant differences between different molecular subtypes in their relationship to CARM1 overexpression. Our results support the value of using CARM1 in prognostic stratification of breast cancer patients and its potential therapeutic implications in targeting treatment. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4116338491022965
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