Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the Rat
Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the Rat
复制标题
半胱胺引起大鼠十二指肠穿孔性溃疡的实验模型
作者：
H. Selye;S. Szabó
人们早就知道，压力本身1或与各种敏化剂（特别是糖皮质激素2,3）联合使用，可引起胃粘膜急性出血性糜烂，已被用作“压力性溃疡”的实验模型。然而，这些糜烂几乎没有穿孔的倾向，并且通常会在几天后消失，除非引发的压力源在愈合之前是致命的。
IT has long been known that exposure to stress, in itself1 or in combination with various sensitizing agents, particularly glucocorticoids2,3, can produce acute haemorrhagic erosions of the gastric mucosa which have been used as experimental models of “stress ulcers”. However, these erosions have little, if any, tendency to perforate and usually disappear after a few days unless the eliciting Stressor is fatal before healing can occur.