Comparison of characteristics from White- and Black-Americans with venous thromboembolism: A cross-sectional study
Comparison of characteristics from White- and Black-Americans with venous thromboembolism: A cross-sectional study
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DOI：
10.1002/ajh.21735
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发表时间：
2010-07-01
影响因子：
12.8
通讯作者：
Philipp, Claire S.
中科院分区：
文献类型：
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作者：
Heit, John A.;Beckman, Michele G.;Philipp, Claire S.
与白人相比，美国黑人的静脉血栓栓塞症(VTE)发病率可能高出40%。然而，VTE的其他特征和风险因素是否因种族而异尚不确定。为了比较患有VTE的美国白人和黑人的人口学和基线特征，我们使用了从2003年8月至2009年3月在七个疾病控制中心(CDC)血栓和止血中心登记的连续自愿成年人的前瞻性数据。这些特征在白人(n=2002)和黑人(n=395)被客观诊断为VTE的人群中进行了比较，包括总体上，以及按年龄和性别。与白人相比，黑人患肺栓塞(PE)的比例明显更高，包括黑人女性中的特发性PE，黑人女性的比例也明显更高。黑人的平均BMI显著较高，而因近期手术、创伤或感染、VTE家族史和有记录的血栓形成(仅从因子V莱顿和凝血酶原G20210A患病率降低)而出现的比例显著较低。相反，黑人患高血压、糖尿病、慢性肾脏疾病和透析、艾滋病毒和镰状细胞疾病的比例明显更高。与白人女性相比，黑人女性最近使用口服避孕药或激素治疗的比例明显较低。我们得出结论，白人和黑人在人口统计学和基线特征方面存在显著差异，这些特征可能是VTE的危险因素。在黑人中，短暂性VTE危险因素和特发性VTE的患病率分别较低和较高，这表明遗传性可能在美国黑人VTE的病因学中起重要作用。上午好。J.血醇。2010年，85：467-471。(C)2010年Wiley-Liss公司
When compared with Whites, Black-Americans may have a 40% higher incidence venous thromboembolism (VTE) incidence. However, whether other VTE characteristics and risk factors vary by race is uncertain. To compare demographic and baseline characteristics among White- and Black-Americans with VTE, we used data prospectively collected from consecutive consenting adults enrolled in seven Centers for Disease Control (CDC) Thrombosis and Hemostasis Centers from August 2003 to March 2009. These characteristics were compared among Whites (n = 2002) and Blacks (n = 395) with objectively diagnosed VTE, both overall, and by age and gender. When compared with Whites, Blacks had a significantly higher proportion with pulmonary embolism (PE), including idiopathic PE among Black women, and a significantly higher proportion of Blacks were women. Blacks had a significantly higher mean BMI and a significantly lower proportion with recent surgery, trauma or infection, family history of VTE, and documented thrombophilia (solely from reduced factor V Leiden and prothrombin G20210A prevalence). Conversely, Blacks had a significantly higher proportion with hypertension, diabetes mellitus, chronic renal disease and dialysis, HIV, and sickle cell disease. When compared with White women, Black women had a significantly lower proportion with recent oral contraceptive use or hormone therapy. We conclude that Whites and Blacks differ significantly regarding demographic and baseline characteristics that may be risk factors for VTE. The prevalence of transient VTE risk factors and idiopathic VTE among Blacks appears to be lower and higher, respectively, suggesting that heritability may be important in the etiology of VTE among Black-Americans. Am. J. Hematol. 85:467-471, 2010. (C) 2010 Wiley-Liss, Inc.