3-Mercaptopropanol as a traceless linker for chemical and enzymatic synthesis of oligosaccharides.
3-Mercaptopropanol as a traceless linker for chemical and enzymatic synthesis of oligosaccharides.
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DOI：
10.1021/ol062922y
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发表时间：
2007-01
期刊：
影响因子：
5.2
通讯作者：
N. Merbouh;F. Wallner;Oana M. Cociorva;P. Seeberger
中科院分区：
文献类型：
--
作者：
N. Merbouh;F. Wallner;Oana M. Cociorva;P. Seeberger
受保护的碳水化合物的还原端可以通过 3-巯基乙醇连接体的光化学安装配备一系列糖苷配基。该连接体在化学和酶糖基化反应过程中是稳定的，但可以轻松有效地激活以将寡糖与不同的亲核体偶联。这种方法可以直接获取一系列作为碳水化合物修饰酶探针的分子。 [反应：见正文]。
The reducing end of protected carbohydrates can be equipped with a series of aglycones via the photochemical installation of a 3-mercaptoethanol linker. This linker is stable during chemical and enzymatic glycosylation reactions but can be activated readily and efficiently to couple oligosaccharides with different nucleophiles. This approach provides straightforward access to a range of molecules that serve as probes for carbohydrate modifying enzymes. [reaction: see text].