Myelination-independent functions of oligodendrocyte precursor cells in health and disease.
Myelination-independent functions of oligodendrocyte precursor cells in health and disease.
复制标题
少突胶质细胞前体细胞在健康和疾病中的髓鞘形成独立功能。
DOI：
10.1038/s41593-023-01423-3
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发表时间：
2023
影响因子：
25
通讯作者：
Xiao Y
中科院分区：
文献类型：
--
作者：
Xiao Y
少突胶质细胞前体细胞（OPC）是在整个CNS中发现的组织驻留神经胶质细胞的群体，构成所有CNS细胞的约5%，并且从发育持续到成年和衰老。OPCs的典型作用是产生髓鞘化少突胶质细胞。然而，长期以来，人们一直认为OPC除了作为前体的传统作用之外还有其他功能。在这个角度来看，我们提供了一个概述的多种髓鞘独立的功能，已被描述为OPCs的神经元发育，血管生成，炎症反应，轴突再生和最近发现的作用，在神经回路重塑的背景下。
Oligodendrocyte precursor cells (OPCs) are a population of tissue-resident glial cells found throughout the CNS, constituting approximately 5% of all CNS cells and persisting from development to adulthood and aging. The canonical role of OPCs is to give rise to myelinating oligodendrocytes. However, additional functions of OPCs beyond this traditional role as precursors have been suggested for a long time. In this Perspective, we provide an overview of the multiple myelination-independent functions that have been described for OPCs in the context of neuron development, angiogenesis, inflammatory response, axon regeneration and their recently discovered roles in neural circuit remodeling.