Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility.
Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility.
复制标题
DOI：
10.3389/fnmol.2017.00199
复制
发表时间：
2017
影响因子：
4.8
通讯作者：
Gao D
中科院分区：
文献类型：
--
作者：
Ayanlaja AA;Xiong Y;Gao Y;Ji G;Tang C;Abdikani Abdullah Z;Gao D
神经元迁移是神经系统发育的关键过程。神经元迁移的缺陷与无脑回畸形、皮质下带状异位（SBH）和巨脑回等疾病有关。双皮质素（DCX）是神经发生中的一个重要因素，这种蛋白质的突变会损害神经元迁移，导致几种病理状况。尽管DCX能够调节和稳定微管（MT）以确保有效的迁移，但执行这些功能的机制仍然知之甚少。与此同时，关于肿瘤发生和发展为癌症的过程以及迁移和侵入正常细胞的能力存在差距。一些研究表明，DCX参与癌症转移。DCX和MT之间的不稳定相互作用使细胞骨架组织不稳定，导致细胞的无序运动，这一过程可能与癌细胞的不受控制的迁移有关。然而，其基本机制是复杂的，需要进一步澄清。因此，探索这种分子的重要性和迄今为止已知的特征将拓宽我们的理解，并阐明相关神经系统疾病的潜在治疗方法。本文综述了DCX的特点、功能及其与其他蛋白质的关系。我们还概述了它在癌细胞中的作用，并强调了研究其基因突变的重要性。
Neuronal migration is a critical process in the development of the nervous system. Defects in the migration of the neurons are associated with diseases like lissencephaly, subcortical band heterotopia (SBH), and pachygyria. Doublecortin (DCX) is an essential factor in neurogenesis and mutations in this protein impairs neuronal migration leading to several pathological conditions. Although, DCX is capable of modulating and stabilizing microtubules (MTs) to ensure effective migration, the mechanisms involved in executing these functions remain poorly understood. Meanwhile, there are existing gaps regarding the processes that underlie tumor initiation and progression into cancer as well as the ability to migrate and invade normal cells. Several studies suggest that DCX is involved in cancer metastasis. Unstable interactions between DCX and MTs destabilizes cytoskeletal organization leading to disorganized movements of cells, a process which may be implicated in the uncontrolled migration of cancer cells. However, the underlying mechanism is complex and require further clarification. Therefore, exploring the importance and features known up to date about this molecule will broaden our understanding and shed light on potential therapeutic approaches for the associated neurological diseases. This review summarizes current knowledge about DCX, its features, functions, and relationships with other proteins. We also present an overview of its role in cancer cells and highlight the importance of studying its gene mutations.