Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy
Morphology of corneal nerves in soft contact lens wear. A comparative study using confocal microscopy
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DOI：
10.1046/j.1475-1313.2003.00106.x
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发表时间：
2003-03-01
影响因子：
2.9
通讯作者：
Efron, N
中科院分区：
文献类型：
--
作者：
Oliveira-Soto, L;Efron, N
本研究的目的是使用Tomey Confoscan共聚焦显微镜（40倍/0.75物镜）评估软性隐形眼镜佩戴者的角膜神经支配。三个不同的年龄和性别匹配的受试者组参与其中，包括长期软性（水凝胶和硅-水凝胶）隐形眼镜佩戴者、过夜软性（水凝胶）隐形眼镜佩戴者和非隐形眼镜佩戴者。为了研究角膜神经的分布和形态，客观地测量、主观地评价或分级了许多变量。对于大多数评估参数，没有发现统计学上的显著差异。然而，定性观察显示角膜神经外观在不同受试者组之间存在显著差异；角膜水肿程度是主要的致病因素。总之，用共聚焦显微镜观察，短期（过夜佩戴）和长期（延长佩戴12个月）软性隐形眼镜佩戴都不会影响角膜神经的形态和/或分布。
The aim of this study was to evaluate corneal innervation in soft contact lens wearers using the Tomey Confoscan confocal microscope (40x/0.75 objective lens). Three distinct age- and sex-matched subject groups were involved, including extended soft (hydrogel and silicone-hydrogel) contact lens wearers, overnight soft (hydrogel) contact lens wearers, and non contact lens wearers. A number of variables were objectively measured, subjectively evaluated, or graded in order to investigate the distribution and morphology of corneal nerves. For most of the evaluated parameters, no statistically significant differences were found. However, qualitative observations showed noticeable differences in corneal nerve appearance among the different subject groups; the degree of corneal oedema was suggested as the main causative factor. In conclusion, neither the short-term (overnight wear) nor the long-term (12-month extended wear) soft contact lens wear appeared to affect the morphology and/or distribution of corneal nerves as viewed with confocal microscopy.