Bone density and 25-hydroxyvitamin D level in extrahepatic biliary atresia
Bone density and 25-hydroxyvitamin D level in extrahepatic biliary atresia
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DOI：
10.1007/s003830100003
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发表时间：
2001-11-01
影响因子：
1.8
通讯作者：
Poovorawan, Y
中科院分区：
文献类型：
--
作者：
Chongsrisawat, V;Ruttanamongkol, P;Poovorawan, Y
胆道闭锁（BA）是一种常见的胆汁淤积性胃肠道疾病，影响婴儿和儿童。本研究的目的是评估42例（20例有黄疸和22例无黄疸）诊断为肝外BA的骨矿物质含量和血清25-羟基维生素D（HVD）水平。进行体格检查和人体测量营养评估。研究包括肝功能检查和血清钙（Ca）。磷酸盐（P）、镁（Mg）。和25-HVD水平。双能X线骨密度仪用于测量腰椎（L-1-L-4）的骨密度（BMD）。结果显示，有黄疸者骨质疏松16例（80%），无黄疸者仅3例（13.6%）（P < 0.05）。所有患者的血清Ca和P水平均正常。仅1例非黄疸患者血清镁水平较低。血清25-HVD水平（平均SD）分别为20.71 +/- 8.24、16.12 +/- 4.3和9.18 +/- 5.84 ng/ml。骨密度正常的受试者（n = 7）。骨量减少（n = 1）。骨质疏松11例。骨疾病是B.A.长期存活者中众所周知的并发症。迄今其发病机制至今仍不清楚。因为，正如目前的研究所表明的那样。黄疸患者比非黄疸患者更频繁地发生骨质疏松症。高胆红素血症可能有影响。在这些患者中，骨矿物质缺乏症的早期检测方法是骨密度测量（非侵入性方法），而不是测量血清Ca、P和Mg水平。
Biliary atresia (BA) represents a common cholestatic affliction of the gastrointestinal tract affecting infants and children. The objective of the present study was to evaluate 42 patients (20 with and 22 without jaundice) diagnosed with extrahepatic BA for bone mineral content and serum 25-hydroxyvitamin D (HVD) levels. physical examination and anthropometric nutritional assessment were performed. The investigation included liver function tests and serum calcium (Ca). phosphate (P), magnesium (Mg). and 25-HVD levels. Dual-energy X-ray absorptiometry US used to measure the bone mineral density (BMD) Of the lumbar spine (L-1-L-4). Our results showed that 16 jaundiced patients (80%) and only 3 nonjaundiced patients (13.6%) showed osteoporosis (P < 0.05). All patients had normal serum Ca and P levels. Only I nonjaundiced patient had a low serum Mg level. Serum 25-HVD levels (mean SD) were 20.71 +/- 8.24, 16.12 +/- 4.3, and 9.18 +/- 5.84 ng/ml. respectively, in subjects with normal bone density (n = 7). osteopenia (n = 1). and osteoporosis (n = 11). Bone disease represents a well-known complication among long-term survivors of B.A. To date. the pathogenesis has remained unexplained. Since, as demonstrated in the present studs. jaundiced patients develop osteoporosis more frequently than nonjaundiced patients. hyperbilirubinemia may have an influence. Bone-mineral deficiency call be detected earlier by means of BMD measurement (non-invasive method) than by measuring serum Ca, P, and Mg levels in these patients.