Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy.
Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy.
复制标题
利用 IL-7/IL-7Rα 轴改善肿瘤免疫治疗。
DOI：
10.1080/2162402x.2015.1122865
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发表时间：
2016
期刊：
影响因子：
7.2
通讯作者：
Rubinstein,MarkP
中科院分区：
文献类型：
--
作者：
Johnson,CBryce;Wrangle,John;Mehrotra,Shikhar;Li,Zihai;Paulos,ChrystalM;Cole,DavidJ;Surh,CharlesD;Rubinstein,MarkP
IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8+T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8+T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and antitumor immunity.
