In vitro friction testing of contact lenses and human ocular tissues: Effect of proteoglycan 4 (PRG4)
In vitro friction testing of contact lenses and human ocular tissues: Effect of proteoglycan 4 (PRG4)
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DOI：
10.1016/j.triboint.2014.11.022
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发表时间：
2015-09-01
影响因子：
6.2
通讯作者：
Schmidt, T. A.
中科院分区：
文献类型：
--
作者：
Samsom, M.;Chan, A.;Schmidt, T. A.
最近表明，隐形眼镜的摩擦力与体内舒适度相关，较低摩擦力的镜片可提高舒适度。蛋白聚糖4（PRG4）是最近发现的一种眼表边界润滑剂。本研究的目的是测量市售硅水凝胶 (SiHy) 隐形眼镜与人体角膜和眼睑组织的摩擦力，并评估 PRG4 润滑和粘附 SiHy 隐形眼镜的能力。这里采用的体外摩擦测试有效地测量和区分了SiHy隐形眼镜与人眼睑和角膜组织的摩擦系数，并且PRG4起到了有效的边界润滑剂的作用。 (C) 2014 Elsevier Ltd. 保留所有权利。
Contact lens friction was recently shown to correlate with in vivo comfort, with lower friction lenses providing improved comfort. Proteoglycan 4 (PRG4) is a recently discovered ocular surface boundary lubricant. The objectives of this study were to measure the friction of commercially available silicone hydrogel (SiHy) contact lenses against human cornea and eyelid tissues, and evaluate the ability of PRG4 to lubricate, and adhere to, SiHy contact lenses. The in vitro friction test employed here effectively measured and distinguished the SiHy contact lens friction coefficients against human eyelid and cornea tissues, and PRG4 functioned as an effective boundary lubricant. (C) 2014 Elsevier Ltd. All rights reserved.