The dynamics of chromatin states mediated by epigenetic modifications during somatic cell reprogramming.
The dynamics of chromatin states mediated by epigenetic modifications during somatic cell reprogramming.
复制标题
体细胞重编程过程中表观遗传修饰介导的染色质状态动态
DOI：
10.3389/fcell.2023.1097780
复制
发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
体细胞重编程（Somatic cell reprogramming， SCR）是指通过多种方法将已分化的体细胞转化为全能或多能细胞的过程。体细胞重编程也为研究基于染色质的因子在建立和维持全能性或多能性中的作用提供了一个平台，因为全能性或多能性相关基因的高表达通常需要活跃的染色质状态。最近在植物或哺乳动物中的一些研究揭示了表观遗传修饰通过改变其染色质状态来调节全能性或多能性基因表达的分子机制。在这篇综述中，我们全面概述了在体细胞向全能或多能细胞重编程过程中表观遗传修饰和染色质状态的动态变化。此外，我们阐明了体细胞重编程过程中DNA甲基化、组蛋白修饰、组蛋白变异和染色质重塑的潜在作用，这将为开发高效细胞重编程的可靠策略铺平道路。
Somatic cell reprogramming (SCR) is the conversion of differentiated somatic cells into totipotent or pluripotent cells through a variety of methods. Somatic cell reprogramming also provides a platform to investigate the role of chromatin-based factors in establishing and maintaining totipotency or pluripotency, since high expression of totipotency- or pluripotency-related genes usually require an active chromatin state. Several studies in plants or mammals have recently shed light on the molecular mechanisms by which epigenetic modifications regulate the expression of totipotency or pluripotency genes by altering their chromatin states. In this review, we present a comprehensive overview of the dynamic changes in epigenetic modifications and chromatin states during reprogramming from somatic cells to totipotent or pluripotent cells. In addition, we illustrate the potential role of DNA methylation, histone modifications, histone variants, and chromatin remodeling during somatic cell reprogramming, which will pave the way to developing reliable strategies for efficient cellular reprogramming.
通过微阵列定义人类多能干细胞多能性获得和维持特异的差异甲基化区域
影响因子：
3.7
作者：
He W;Kang X;Du H;Song B;Lu Z;Huang Y;Wang D;Sun X;Yu Y;Fan Y
通讯作者：
Fan Y